A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism
Identifieur interne : 000053 ( Main/Exploration ); précédent : 000052; suivant : 000054A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism
Auteurs : Thao Thi Thu Nguyen ; Tomomi Higashi ; Yasuhiro Kambayashi ; Enoch Olando Anyenda ; Yoshimasa Michigami ; Johsuke Hara ; Masaki Fujimura [Japon] ; Hiromasa Tsujiguchi ; Masami Kitaoka ; Hiroki Asakura ; Daisuke Hori ; Yuri Hibino ; Tadashi Konoshita ; Hiroyuki NakamuraSource :
- International Journal of Environmental Research and Public Health [ 1661-7827 ] ; 2016.
Abstract
The association between heavy metals exposure and respiratory diseases or allergic sensitization showing high serum immunoglobulin E (IgE) has been suggested. However, previous findings have been inconsistent and the mechanisms responsible remain unclear. We evaluated heavy metal exposure and its association with coughing, itchy eyes in chronic cough patients with different IgE levels. Ninety outpatients in Kanazawa University Hospital were recruited between January–June 2011. Subjects whose total IgE measured by radioimmunosorbent test were asked to record their daily symptoms. We collected daily total suspended particles (TSP) from which concentrations of calcium (Ca), cadmium (Cd), chromium (Cr), iron (Fe), manganese (Mn), nickel (Ni), and lead (Pb) were determined then divided into high and low level groups. Generalized estimating equations were applied to compute the relationship between concentrations of these metals and symptoms. All metals at high levels were significantly associated with itchy eyes compared with low levels, with exception of Ca, the six others were significant in patients with IgE < 250 IU/mL. Cd, Fe, Mn had association with coughing (odds ratio-OR (95% confidence interval-CI): 1.13 (1.03, 1.24), 1.22 (1.05, 1.42), and 1.13 (1.01, 1.27), respectively), this relationship remained significant for Cd (OR (95% CI): 1.14 (1.03, 1.27)) and Mn (OR (95% CI): 1.15 (1.00, 1.31)) in patients with lower IgE. Our findings demonstrate the relationship between aerial heavy metals and itchy eyes, coughing in chronic cough patients, suggesting these symptoms may be due to a non-IgE mediated mechanism.
Url:
DOI: 10.3390/ijerph13010110
PubMed: 26751467
PubMed Central: 4730501
Affiliations:
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(Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Michigami, Yoshimasa" sort="Michigami, Yoshimasa" uniqKey="Michigami Y" first="Yoshimasa" last="Michigami">Yoshimasa Michigami</name><affiliation><nlm:aff id="af3-ijerph-13-00110">Environment Preservation Center, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan;<email>mitigami@t.kanazawa-u.ac.jp</email></nlm:aff></affiliation></author><author><name sortKey="Hara, Johsuke" sort="Hara, Johsuke" uniqKey="Hara J" first="Johsuke" last="Hara">Johsuke Hara</name><affiliation><nlm:aff id="af4-ijerph-13-00110">Respiratory Medicine, Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>hara0728@gmail.com</email> (J.H.);<email>fujimura@nanao.hosp.go.jp</email> (M.F.)</nlm:aff></affiliation></author><author><name sortKey="Fujimura, Masaki" sort="Fujimura, Masaki" uniqKey="Fujimura M" first="Masaki" last="Fujimura">Masaki Fujimura</name><affiliation><nlm:aff id="af4-ijerph-13-00110">Respiratory Medicine, Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>hara0728@gmail.com</email> (J.H.);<email>fujimura@nanao.hosp.go.jp</email> (M.F.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-ijerph-13-00110">Respiratory Medicine, National Hospital Organization Nanao Hospital, 3-1 Mattou-machi Yabe, Nanao, Ishikawa 926-8531, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Respiratory Medicine, National Hospital Organization Nanao Hospital, 3-1 Mattou-machi Yabe, Nanao, Ishikawa 926-8531</wicri:regionArea><wicri:noRegion>Ishikawa 926-8531</wicri:noRegion></affiliation></author><author><name sortKey="Tsujiguchi, Hiromasa" sort="Tsujiguchi, Hiromasa" uniqKey="Tsujiguchi H" first="Hiromasa" last="Tsujiguchi">Hiromasa Tsujiguchi</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Kitaoka, Masami" sort="Kitaoka, Masami" uniqKey="Kitaoka M" first="Masami" last="Kitaoka">Masami Kitaoka</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Asakura, Hiroki" sort="Asakura, Hiroki" uniqKey="Asakura H" first="Hiroki" last="Asakura">Hiroki Asakura</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> 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uniqKey="Hibino Y" first="Yuri" last="Hibino">Yuri Hibino</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Konoshita, Tadashi" sort="Konoshita, Tadashi" uniqKey="Konoshita T" first="Tadashi" last="Konoshita">Tadashi Konoshita</name><affiliation><nlm:aff id="af6-ijerph-13-00110">Third Department of Internal Medicine, Fukui University School of Medicine, Eiheiji, Fukui 910-1193, 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type="wicri:Area/Main/Exploration">000053</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism</title><author><name sortKey="Nguyen, Thao Thi Thu" sort="Nguyen, Thao Thi Thu" uniqKey="Nguyen T" first="Thao Thi Thu" last="Nguyen">Thao Thi Thu Nguyen</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Higashi, Tomomi" sort="Higashi, Tomomi" uniqKey="Higashi T" first="Tomomi" last="Higashi">Tomomi Higashi</name><affiliation><nlm:aff id="af2-ijerph-13-00110">Department of Hygiene, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>tomotomo@med.kanazawa-u.ac.jp</email></nlm:aff></affiliation></author><author><name sortKey="Kambayashi, Yasuhiro" sort="Kambayashi, Yasuhiro" uniqKey="Kambayashi Y" first="Yasuhiro" last="Kambayashi">Yasuhiro Kambayashi</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Anyenda, Enoch Olando" sort="Anyenda, Enoch Olando" uniqKey="Anyenda E" first="Enoch Olando" last="Anyenda">Enoch Olando Anyenda</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Michigami, Yoshimasa" sort="Michigami, Yoshimasa" uniqKey="Michigami Y" first="Yoshimasa" last="Michigami">Yoshimasa Michigami</name><affiliation><nlm:aff id="af3-ijerph-13-00110">Environment Preservation Center, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan;<email>mitigami@t.kanazawa-u.ac.jp</email></nlm:aff></affiliation></author><author><name sortKey="Hara, Johsuke" sort="Hara, Johsuke" uniqKey="Hara J" first="Johsuke" last="Hara">Johsuke Hara</name><affiliation><nlm:aff id="af4-ijerph-13-00110">Respiratory Medicine, Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>hara0728@gmail.com</email> (J.H.);<email>fujimura@nanao.hosp.go.jp</email> (M.F.)</nlm:aff></affiliation></author><author><name sortKey="Fujimura, Masaki" sort="Fujimura, Masaki" uniqKey="Fujimura M" first="Masaki" last="Fujimura">Masaki Fujimura</name><affiliation><nlm:aff id="af4-ijerph-13-00110">Respiratory Medicine, Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>hara0728@gmail.com</email> (J.H.);<email>fujimura@nanao.hosp.go.jp</email> (M.F.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-ijerph-13-00110">Respiratory Medicine, National Hospital Organization Nanao Hospital, 3-1 Mattou-machi Yabe, Nanao, Ishikawa 926-8531, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Respiratory Medicine, National Hospital Organization Nanao Hospital, 3-1 Mattou-machi Yabe, Nanao, Ishikawa 926-8531</wicri:regionArea><wicri:noRegion>Ishikawa 926-8531</wicri:noRegion></affiliation></author><author><name sortKey="Tsujiguchi, Hiromasa" sort="Tsujiguchi, Hiromasa" uniqKey="Tsujiguchi H" first="Hiromasa" last="Tsujiguchi">Hiromasa Tsujiguchi</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Kitaoka, Masami" sort="Kitaoka, Masami" uniqKey="Kitaoka M" first="Masami" last="Kitaoka">Masami Kitaoka</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Asakura, Hiroki" sort="Asakura, Hiroki" uniqKey="Asakura H" first="Hiroki" last="Asakura">Hiroki Asakura</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Hori, Daisuke" sort="Hori, Daisuke" uniqKey="Hori D" first="Daisuke" last="Hori">Daisuke Hori</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Hibino, Yuri" sort="Hibino, Yuri" uniqKey="Hibino Y" first="Yuri" last="Hibino">Yuri Hibino</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Konoshita, Tadashi" sort="Konoshita, Tadashi" uniqKey="Konoshita T" first="Tadashi" last="Konoshita">Tadashi Konoshita</name><affiliation><nlm:aff id="af6-ijerph-13-00110">Third Department of Internal Medicine, Fukui University School of Medicine, Eiheiji, Fukui 910-1193, Japan;<email>konosita@u-fukui.ac.jp</email></nlm:aff></affiliation></author><author><name sortKey="Nakamura, Hiroyuki" sort="Nakamura, Hiroyuki" uniqKey="Nakamura H" first="Hiroyuki" last="Nakamura">Hiroyuki Nakamura</name><affiliation><nlm:aff id="af1-ijerph-13-00110">Department of Environmental Health and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan;<email>toi_fs@yahoo.com</email> (T.T.T.N.);<email>ykamba@med.kanazawa-u.ac.jp</email> (Y.K.);<email>enolany@yahoo.com</email> (E.O.A.);<email>t-hiromasa@med.kanazawa-u.ac.jp</email> (H.T.);<email>m-ymzk16@stu.kanazawa-u.ac.jp</email> (M.K.);<email>heros@stu.kanazawa-u.ac.jp</email> (H.A.);<email>hori_d@mbr.nifty.com</email> (D.H.);<email>hibino@staff.kanazawa-u.ac.jp</email> (Y.H.)</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Environmental Research and Public Health</title><idno type="ISSN">1661-7827</idno><idno type="eISSN">1660-4601</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The association between heavy metals exposure and respiratory diseases or allergic sensitization showing high serum immunoglobulin E (IgE) has been suggested. However, previous findings have been inconsistent and the mechanisms responsible remain unclear. We evaluated heavy metal exposure and its association with coughing, itchy eyes in chronic cough patients with different IgE levels. Ninety outpatients in Kanazawa University Hospital were recruited between January–June 2011. Subjects whose total IgE measured by radioimmunosorbent test were asked to record their daily symptoms. We collected daily total suspended particles (TSP) from which concentrations of calcium (Ca), cadmium (Cd), chromium (Cr), iron (Fe), manganese (Mn), nickel (Ni), and lead (Pb) were determined then divided into high and low level groups. Generalized estimating equations were applied to compute the relationship between concentrations of these metals and symptoms. All metals at high levels were significantly associated with itchy eyes compared with low levels, with exception of Ca, the six others were significant in patients with IgE < 250 IU/mL. Cd, Fe, Mn had association with coughing (odds ratio-OR (95% confidence interval-CI): 1.13 (1.03, 1.24), 1.22 (1.05, 1.42), and 1.13 (1.01, 1.27), respectively), this relationship remained significant for Cd (OR (95% CI): 1.14 (1.03, 1.27)) and Mn (OR (95% CI): 1.15 (1.00, 1.31)) in patients with lower IgE. Our findings demonstrate the relationship between aerial heavy metals and itchy eyes, coughing in chronic cough patients, suggesting these symptoms may be due to a non-IgE mediated mechanism.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bae, S" uniqKey="Bae S">S. Bae</name></author><author><name sortKey="Pan, X C" uniqKey="Pan X">X.-C. Pan</name></author><author><name sortKey="Kim, S Y" uniqKey="Kim S">S.-Y. Kim</name></author><author><name sortKey="Park, K" uniqKey="Park K">K. Park</name></author><author><name sortKey="Kim, Y H" uniqKey="Kim Y">Y.-H. Kim</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H. 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Igishi</name></author><author><name sortKey="Yamasaki, A" uniqKey="Yamasaki A">A. Yamasaki</name></author><author><name sortKey="Burioka, N" uniqKey="Burioka N">N. Burioka</name></author><author><name sortKey="Takeuchi, H" uniqKey="Takeuchi H">H. Takeuchi</name></author><author><name sortKey="Sako, T" uniqKey="Sako T">T. Sako</name></author><author><name sortKey="Touge, H" uniqKey="Touge H">H. Touge</name></author><author><name sortKey="Nakamoto, M" uniqKey="Nakamoto M">M. Nakamoto</name></author><author><name sortKey="Hasegawa, Y" uniqKey="Hasegawa Y">Y. Hasegawa</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Anyenda, Enoch Olando" sort="Anyenda, Enoch Olando" uniqKey="Anyenda E" first="Enoch Olando" last="Anyenda">Enoch Olando Anyenda</name><name sortKey="Asakura, Hiroki" sort="Asakura, Hiroki" uniqKey="Asakura H" first="Hiroki" last="Asakura">Hiroki Asakura</name><name sortKey="Hara, Johsuke" sort="Hara, Johsuke" uniqKey="Hara J" first="Johsuke" last="Hara">Johsuke Hara</name><name sortKey="Hibino, Yuri" sort="Hibino, Yuri" uniqKey="Hibino Y" first="Yuri" last="Hibino">Yuri Hibino</name><name sortKey="Higashi, Tomomi" sort="Higashi, Tomomi" uniqKey="Higashi T" first="Tomomi" last="Higashi">Tomomi Higashi</name><name sortKey="Hori, Daisuke" sort="Hori, Daisuke" uniqKey="Hori D" first="Daisuke" last="Hori">Daisuke Hori</name><name sortKey="Kambayashi, Yasuhiro" sort="Kambayashi, Yasuhiro" uniqKey="Kambayashi Y" first="Yasuhiro" last="Kambayashi">Yasuhiro Kambayashi</name><name sortKey="Kitaoka, Masami" sort="Kitaoka, Masami" uniqKey="Kitaoka M" first="Masami" last="Kitaoka">Masami Kitaoka</name><name sortKey="Konoshita, Tadashi" sort="Konoshita, Tadashi" uniqKey="Konoshita T" first="Tadashi" last="Konoshita">Tadashi Konoshita</name><name sortKey="Michigami, Yoshimasa" sort="Michigami, Yoshimasa" uniqKey="Michigami Y" first="Yoshimasa" last="Michigami">Yoshimasa Michigami</name><name sortKey="Nakamura, Hiroyuki" sort="Nakamura, Hiroyuki" uniqKey="Nakamura H" first="Hiroyuki" last="Nakamura">Hiroyuki Nakamura</name><name sortKey="Nguyen, Thao Thi Thu" sort="Nguyen, Thao Thi Thu" uniqKey="Nguyen T" first="Thao Thi Thu" last="Nguyen">Thao Thi Thu Nguyen</name><name sortKey="Tsujiguchi, Hiromasa" sort="Tsujiguchi, Hiromasa" uniqKey="Tsujiguchi H" first="Hiromasa" last="Tsujiguchi">Hiromasa Tsujiguchi</name></noCountry><country name="Japon"><noRegion><name sortKey="Fujimura, Masaki" sort="Fujimura, Masaki" uniqKey="Fujimura M" first="Masaki" last="Fujimura">Masaki Fujimura</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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